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Exposure of immune effector cells (macrophages, T-cells, and NK cells) to these temperatures promotes: (i) migration of immune cells to tumor sites, improving immune surveillance, (ii) upregulation of surface molecules involved in antigen presentation, (iii) release of cytokines and other inflammatory mediators (e.g., tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-6, IL-10, and IL-12), (iv) proliferation of immune cells, and (v) cytotoxicity against tumor cells (see Table 1)
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