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The most parsimonious explanation for the presence of m + 2 isotopologues in TCA cycle intermediates is the condensation of 13 C 6 -glucose-derived acetyl-CoA, arising from the activity of pyruvate dehydrogenase, with unlabeled oxaloacetate via the citrate synthase reaction [27, 28]

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“A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease.” Molecular & Cellular Proteomics 8: 720–734