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Following further optimization in the PC activation process, for 1 Β΅M (62.5 Β΅g/ml) PC, the optimal thrombin concentration was 85 nM or 3.12 Β΅g/ml (8.5% molar ratio or 5% w/w ratio to PC), whereas higher thrombin concentrations did not result in higher APC generation (see Supplementary Fig
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Figure 6 illustrated the effect of cyclophosphamide on Sirt1/NF-kB axis
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