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To understand these conflicting findings, it is important to analyze the level of autophagy itself, as excessively high or low levels may be detrimental

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Moreover, in contrast to protein oxidation, lipid peroxidation, and cell death following Aβ40 or Aβ42 addition to neuronal cultures, none of these occurred with the norleucine-substituted Aβ peptide (112–114), i.e., the Met35 residue of Aβ42 was hinted at as being important in the free radical associated with this neurotoxic peptide