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Although the unavailability of Geref Diagnostic (Serono) to complete the protocol as initially designed greatly decreased the statistical power of the study to detect a significant difference in the accuracy of the macimorelin vs the arginine+GHRH test in diagnosing AGHD, the results on the subgroup of subjects whom we could test with both agents show that macimorelin is at least as accurate in diagnosing this condition as arginine+GHRH, and it is preferred by patients