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Ghrelin stimulates the secretion of GH via binding to its receptor GHS-R1a, which activates a G-protein Ga11, and this activated G-protein then stimulates Phospholipase C
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Used together with atropine to treat poisoning caused by organophosphate cholinesterase inhibitors 2-PAM is not effective against the chemically different โcarbamateโ type cholinesterase inhibitors (such as neostigmine and pyridostigmine) because carbamates do not have phosphate groups and do not undergo โagingโ
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