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Noteworthy, only a few studies have paid attention to the effects of AGE and SAC on the main prooxidant enzymes (XO, NADPH oxidase, or COX), so the mechanisms involved in the possible inhibitory actions of these compounds have been not elucidated yet
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Through the SIRT6/p-Nrf2/GPX4 pathway, melatonin enhances antioxidant defenses and activates antiferroptosis pathways, leading to a reduction in senescence markers
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