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When exposing SH-SAMMS bound with Cd(II), Pb(II), and Hg(II) to Caco-2 cells (possessing many properties of the intestinal epithelium), there was no leachate of the four metal ions from SH-SAMMS across the Caco-2 monolayer and no decrease in trans-epithelial electrical resistance (TEER) across the exposed cell monolayers, thus SH-SAMMS did not damage the cell monolayer

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